Next-Generation Artificial Skin Models
Next-Generation Artificial Skin Models

Growing global chorus for alternatives to animal testing

There is a huge global demand for alternatives to animal testing in cosmetic and pharmaceutical development. Cosmetic testing on animals was completely banned in the European Union in 2013, and a growing chorus around the world is demanding the same restrictions on drug companies. However, previous artificial skin models have been inadequate in terms of their utility in evaluating skin function, limiting their applicability mainly to safety assessments. This need drove us to develop an innovative model that well replicates human skin in terms of both structure and function, allowing researchers to predict the effects of functional cosmetics and pharmaceuticals on humans.

Our second-generation artificial skin model

The first generation of artificial skin models consists of the existing ones used in safety assessments. Our second-generation model possesses a three-dimensional structure, with epidermal and dermal layers, and responds to physiologically active substances, allowing researchers to evaluate new functional compounds. This paradigm shift away from mere safety evaluation will aid in the discovery of new functional compounds and substances needed in the healthcare industry, and the development of scientifically proven, groundbreaking new products.

Our third-generation artificial skin model: accessory organs for more-realistic function

Besides the epidermis and dermis, human skin contains so-called accessory organs such as hair follicles and sebaceous and sweat glands. Pores, sebum, and sweat are crucial to the skin’s natural moisture retention and barrier functions. The structural and functional differences between natural skin and existing artificial skin models due to the absence of accessory organs in the latter creates several major issues. For one, normal skin barrier function is compromised by a lack of sebum secretion. Similarly, the lack of pores means that the transdermal absorption of compounds cannot be evaluated accurately, and their effects on accessory skin organs cannot be verified.
Through state-of-the-art technological development, we were the first in the world to successfully regenerate hair follicles, sebaceous glands, and other accessory organs. We applied our approach to develop an innovative 3D model of artificial human skin containing accessory organs, capable of completely replicating natural skin function.

Custom models based on our clients’ needs

We are confident that our revolutionary 3D artificial skin model can be customized to different target populations, based on ethnicity, gender, disease, or other client requirements. Such custom models help businesses develop more-advanced and higher-quality products for their customers, thereby greatly contributing to the healthcare industry as well as the health of people around the world.